ABSTRACT
Background: Worldwide, diabetes mellitus is a major health problem leading to remarkable mortality and morbidity day by day. Adenosine deaminase (ADA) catalyzes the irreversible deamination of adenosine to inosine is a polymorphic enzyme which is considered to be related to type 2 diabetes mellitus (T2DM). So, it may be useful in formulating proper guideline for evaluating the glycemic status in T2DM. The aim of the study was to assess the correlation of serum adenosine deaminase (ADA) with glycated heamoglobin (HbA1c) in type 2 diabetics mellitus patients.Material & Methods:It was a cross sectional study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2014 to June 2015. A total number of 150 participants of both sexes were included in this study as the study population. The samples were divided into major two groups. The control group (Group A) consisted of 50 age matched healthy subjects for comparison and the study group (Group B) consisted of 100 type 2 diabetic patients with the age ranging from 40-55 years. Again, depending on HbA1c level, the study group was divided into two subgroups. Group B1 consisted of 50 participants with HbA1c<6.5% and Group B2 consisted of 50 participants with HbA1c>6.5%. The study parameters were including serum ADA, FPG, HbA1c. For statistical analyses one-way ANOVA test, unpaired Student’s test and Pearson’s correlation coefficient (r) test were performed as applicable using SPSS version 20.0.Results:type-2 DM as compared to healthy controls. Again, serum ADA (P<0.001) levels were significantly higher in type2DM with HbA1c ?6.5% than that of type2 DM with HbA1c <6.5%. There is a positive correlation of serum ADA with FPG, HbA1c in type 2 diabetic patients.Conclusion:After analyzing the results of the study, it is concluded that estimation of serum ADA level might be used as a new marker for prediction of glycemic in type2 diabetes mellitus.